News

Job Offer:

PhD position available at the Georg-Speyer-Haus (group Dr. Ursula Dietrich)

Within the Graduate School GRK1172 a PhD position is available in the group of Dr. Ursula Dietrich at the Georg- Speyer- Haus in Frankfurt am Main starting in February 2012.

The project is in the field of HIV-1 vaccine development, in particular the identification of HIV neutralizing antibodies and their epitopes in patients naturally controlling the infection. Candidates should have a first class MSc or diploma (biology or related discipline) and practical experience in molecular biology and cell biology (preferentially in the field of virology). Further information is available at http://www.georg-speyer-haus.de/agdietrich/index.htm.
The GRK1172 provides postgraduate education in all aspects of translational biomedicine.
Applications including a curriculum vitae, certificates (High School and University education), a summary of previous research projects as well as two references should be addressed to:

Dr. Ursula Dietrich
Georg-Speyer-Haus
Paul-Ehrlich-Str. 42-44
60596 Frankfurt, Germany

E-Mail:

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Promotionsstelle – PhD / naturwissenschaftliche/r Doktorand/in
Tumorforschung

Im Institut für Allgemeine Pharmakologie und Toxikologie in der Arbeitsgruppe von Prof. Radeke (Immunpharmakologie) ist ab sofort die Stelle einer/eines Ph.D. Student/in – Naturwissenschaftlichen Doktorand/in im Rahmen eines von Merck Serono für drei Jahre geförderten Projektes des Graduiertenkollegs 1172 Biologicals ist zu besetzen.
Unsere Arbeitsgruppe beschäftigt sich insbesondere mit pathologischen Prozessen wie der Entzündung und der Tumorgenese. In dem Dissertationsprojekt soll die Rolle von Dendritischen Zellen (DC) und ihrer Zytokinpoduktion (IL-12, IL-23) während der Tumorentwicklung näher untersucht werden. Die Experimente konzentrieren sich dabei auf die Auswirkungen einer differentiellen Regulation von IL-12 u.a. durch p47phox (J Immunol. 2009) in einem Mausmodell des Melanoms. Desweiteren sollen Interaktionspartner und Aktivierungsmechanismen dieser Regulation auf molekularer Ebene untersucht werden. Bei positiven Anti-Tumor Effekten sollen gentechnisch veränderte Dendritische Zellen im Krankheitsmodell auf einen möglichen Nutzen von therapeutisch eingesetzter shRNA oder microRNA ausgetestet werden. Die dafür notwendigen Methoden, wie Klonierung, Transfektion und Transduktion werden in Laboren der Sicherheitsstufe 1 und 2 stattfinden.
Der/die Bewerber/in sollte einen Universitätsabschluss in Biologie, Pharmazie, Biochemie oder Biotechnologie und bereits erste Erfahrungen in

• Zellbiologie (Kultur von Säugerzellen)
• Molekularbiologie (Klonierung, Plasmid-Präparation, lentivirale Transduktion)

haben. Sehr wünschenswert sind Kenntnisse in der Immunologie (z.B. Western Blot, FACS und/oder Immunhistochemie) sowie in tierexperimentellen Arbeiten (Betäubung, Applikation von Substanzen, Organentnahme). Vorkenntnisse auf diesem Gebiet werden jedoch nicht vorausgesetzt. Erwartet werden gute Englisch- und PC Kenntnisse. Die Doktorandenstelle ist neben der angebotenen Graduiertenausbildung des Graduiertenkollegs 1172 Biologicals unter dem Dach der Graduiertenschule FIRST organisiert. Es findet ein offizielles Auswahlverfahren mit Erfolgschancen nur für exzellente Bewerber/innen (Durchschnitt <1,5) durch ein Auswahlkomitee statt. Schwerbehinderte Bewerberinnen/Bewerber werden bei gleicher persönlicher und fachlicher Eignung bevorzugt berücksichtigt. Das Klinikum sieht sich verpflichtet, den Anteil an Frauen zu erhöhen. Frauen sind daher ausdrücklich zur Bewerbung aufgefordert.

Die Bewerbung mit Lebenslauf, Lichtbild und Zeugnisse senden Sie bitte an:

Klinikum der Johann Wolfgang Goethe-Universität Frankfurt
Institut für Allg. Pharmakologie und Toxikologie
pharmazentrum frankfurt
Prof. Dr. H.H. Radeke
Theodor-Stern-Kai 7
60590 Frankfurt

oder per Email an:

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A position for a

PhD student (m/f)

is available immediately in the group of Prof. L. Schaefer at the Institute of Pharmacology and Toxicology of the University Hospital in Frankfurt / Main, Germany.

The position includes a fellowship of the Research Training Group „Biologicals“ (GRK 1172). This interdisciplinary network allows PhD students to benefit from the knowledge of diverse disciplines, as well as to acquire important qualifications for their further scientific career.

Our young and international group works in a modern and well-equipped laboratory on the University Hospital’s campus. We study components of the extracellular matrix that - in addition to their structural functions – fulfill tasks as signaling molecules. For instance, proteoglycans of the extracellular matrix can act as an endogenous danger signals and are capable of triggering inflammatory processes (Moreth et al. J Clin Invest 2010; Schaefer L et al. J Clin Invest. 2005; Babelova A et al. J Biol Chem. 2009). The major objective of the PhD project is the identification of novel drug targets for the inhibition of these pro-inflammatory effects.

The applicant should have an excellent degree in biology, biochemistry or a related life science. Knowledge and skills in molecular biology, cell biology and biochemistry, and the willingness to work with animals are desirable. If you are creative, self-motivated and a team player, we will be pleased to receive your application.

If you are interested in working with us, please send your application including (CV with picture) references via e-mail to Prof. Liliana Schaefer (). You may find further information at:

www.pzf.de/allg/research/schaefer.php
www.grk-1172.de

Key references:

1. Moreth K, Brodbeck R, Babelova A, Gretz N, Spieker T, Zeng-Brouwers J, Pfeilschifter J, Young M, Schaefer RM, Schaefer L: The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest 120: 4251-72, 2010

Highlight: Nature Reviews Immunology 11, 6-7 (January 2011) | doi:10.1038/nri2911

2. Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Gröne H-J, Schaefer L: Biglycan: a danger signal that activates the NLRP3 inflammasome via a Toll-like- and P2X-multireceptor complex. J Biol Chem 284:24035-24048, 2009

Editorial choice: L. B. Ray, Tissue Damage Sensor. Sci. Signal. 2, ec301 (2009)

3. Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, Marsche G, Young MF, Mihalik D, Gotte M, Malle E, Schaefer RM, Grone HJ: The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 115:2223-2233, 2005

PhD studentship: Novel approaches for vaccine development

A three-year PhD studentship in the department of virology, section HIV vaccines and AIDS at the Paul-Ehrlich-Institut in Langen under the supervision of Prof. Dr. Barbara Schnierle is available immediately.

The Paul-Ehrlich-Institut, the Federal Agency for Sera and Vaccines in Germany, fulfils a broad range of legal responsibilities in the fields of medicinal products for human and veterinary use, which are supported by research activities in the fields of virology, immunology, allergology, and medical biotechnology.

The project is within the graduate school GRK1172 provides postgraduate education in all aspects of translational biomedicine. In this three year postgraduate program, structured teaching (in English) is combined with interdisciplinary research projects. This project will focus on the development of novel vaccines against infectious diseases.

Candidates should possess a first class MSc (biology, or related discipline) and expertise in virology and molecular biology. Applications consisting of a cover letter indicating personal research goals as well as a full curriculum vitae containing a brief summary of previous research product projects, together with copies of all relevant university certificates should be sent until March 10, 2011 -preferably by email- to: Prof Dr. Barbara Schnierle, Paul-Ehrlich-Institut, Abteilung Virologie FG 2/2, Paul-Ehrlich-Str. 51-59, D-63225 Langen, Tel: 0049-6103-77-5504

Email:
Further details can be found at: www.pei.de and http://www.grk-1172.de

 

Promotionsstelle - Graduiertenkolleg 1172 „Biologicals“

Am pharmazentrum frankfurt des Klinikums der Goethe-Universität Frankfurt ist ab
Juli 2011 eine Stelle für eine/einen Doktorandin/en im Forschungsschwerpunkt ‚Zytokinbiologie’ zu besetzen. Die Stelle beinhaltet ein Stipendium der DFG im Rahmen des Graduiertenkollegs 1172 „Biologicals“ www.grk-1172.de und ist für die Dauer von 3 Jahren vorgesehen.

Das Forschungsprojekt umfasst Arbeiten zu Biologie, Pathophysiologie und potenzieller Nutzung von Interleukin-22 als ‚Target’ oder ‚Tool’ immunpharmakologischer Intervention. Grundkenntnisse und praktische Erfahrungen in molekularbiologischen und zellbiologischen Arbeitsmethoden sind erwünscht. Stellenbewerber/innen sollten ein Studium der Biologie, Biochemie, Pharmazie oder Humanbiologie abgeschlossen haben und ein hohes Maß an Motivation für wissenschaftliches Arbeiten mitbringen.

Literatur:

Heiko Mühl, Malte Bachmann, Josef Pfeilschifter (2011) Inducible NO synthase and antibacterial
host defence in times of Th17/Th22/T22 immunity.
Cell Microbiol (in press, doi: 10.1111/j.1462-5822.2010.01559.x )

Sandra Hoegl, Malte Bachmann, Patrick Scheiermann, Itamar Goren, Christian Hofstetter,
Josef Pfeilschifter, Bernhard Zwissler, Heiko Mühl (2011). Protective Properties of Inhaled
IL-22 in a Model of Ventilator-induced Lung Injury.
Am J Respir Cell Mol Biol 2011 (in press, doi:10.1165/rcmb.2009-0440OC)

Tobias M Bingold, Elisabeth Ziesché, Bertram Scheller, Christian D Sadik, Katharina Franck, Lara
Just, Sven Sartorius, Mathis Wahrmann, Heimo Wissing, Bernhard Zwissler, Josef Pfeilschifter,
Heiko Mühl (2010) Interleukin-22 detected in patients with abdominal sepsis. Shock 34: 337-340

Malte Bachmann, Katharina Horn, Ina Rudloff, Itamar Goren, Martin Holdener, Urs Christen, Nicole
Darsow, Klaus-Peter Hunfeld, Ulrike Koehl, Peter Kind, Josef Pfeilschifter, Peter Kraiczy,
Heiko Mühl (2010) Early Production of IL-22 but Not IL-17 by Peripheral Blood Mononuclear
Cells Exposed to live Borrelia burgdorferi: The Role of Monocytes and Interleukin-1.
PLoS Pathog 6: 10. 10

Ziesché, P Scheiermann, M Bachmann, C D Sadik, C Hofstetter, B Zwissler, J Pfeilschifter, H Mühl
(2009) Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro
and in vivo. Clin Exp Immunol 157: 3. 370-376

Elisabeth Ziesché, Malte Bachmann, Hartmut Kleinert, Josef Pfeilschifter, Heiko Mühl (2007) The
interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in
human colon carcinoma cells. J Biol Chem 282: 22. 16006-16015

Bewerbungen mit den üblichen Unterlagen (Lebenslauf, Lichtbild, Zeugniskopien) richten Sie bitte an:

Prof. Dr. Heiko Mühl
pharmazentrum frankfurt
Allgemeine Pharmakologie und Toxikologie
Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main

Theodor-Stern-Kai 7, Haus 74
D-60590 Frankfurt am Main

Tel.: 069 6301 6962
E-mail:

 

 

PhD Graduate Student Position – Graduate School 1172 „Biologicals“

Starting in February 2011 or later, a PhD position is available in the group of PD Dr. U. Köhl (Laboratory for Stem Cell Transplantation and Immunotherapy) at the Paediatric Haematology and Oncology (head Prof. Dr. T. Klingebiel) of the Goethe-University Frankfurt/ Main.

The position includes a fellowship of the graduate school 1172 „Biologicals“ www.grk-1172.de which is funded by the DFG and is available for at least 3 years.

Description:

Our scientific work focused on the development of new cell-based therapies for the treatment of patients with high-risk leukaemia and tumours. The PhD position is dedicated to an ungoing clinical phase I/II study with natural killer (NK) cells with the goal to improve NK-cell mediated cytotoxicity against tumour cells (Koehl U et al. Blood Cells Mol Dis 33:261, 2004; Zimmermann S et al. JIM 296:63, 2005; Huenecke S et al. J of Immunother 33:200, 2010). Interaction between NK cells and dendritic cells as well as retargeted NK cells transduced with target-specific single chain antibodies will be used to overcome tumour immune escape mechanism, which leads to abrogation of NK cell-mediated cytotoxicity (Kloess S et al. Eur J Immunol, prepublished online 21 Sep 2010). Thereby the influence of NK cells on immune regulation and cellular immune reconstitution post stem cell transplantation (patient monitoring and mouse model) should be investigated (Koenig M et al. BMT 45:613, 2010; Vogler I et al. Mol Ther 18:1330, 2010).

We offer you:

• Individualized supervision and mentoring (focused on immunology) with a highly motivated team
• Structured international PhD program (in English) incl. special courses (i.e. GMP/GLP)
• Modern state-of-the-art laboratories (i.e. 4 flow cytometers, Real-time-PCR, transduction- and selection techniques, culture of primary human immune cells and tumour cells)

Your profile:

• Diploma/Master or equivalent degree preferably in Biology, Pharmacy, Biotechnology, Bioinformatics or related disciplines
• Highly talented and motivated doctoral students with a strong passion for immunology

Please send your application (CV, final school and university certificates, cover letter) by e-mail/mail to:

PD Dr. U. Köhl
Universitätsklinik Frankfurt
Pädiatrische Hämatologie und Onkologie
Labor für Stammzelltransplantation und Immuntherapien

Theodor Stern Kai 7
D- 60596 Frankfurt

E-Mail:

A position for a PhD student (m/f) is available immediately in the group of Prof. L. Schaefer at the Institute of Pharmacology and Toxicology of the University Hospital in Frankfurt / Main, Germany. The position includes a fellowship of the Research Training Group „Biologicals“ which is funded by the German Research Foundation (DFG). This interdisciplinary network allows PhD students to benefit from the knowledge of diverse disciplines, as well as to acquire important qualifications for their further scientific career

Our young and international group works in a modern and well-equipped laboratory on the University Hospital’s campus. We study components of the extracellular matrix that - in addition to their structural functions – fulfill tasks as signaling molecules. For instance, proteoglycans of the extracellular matrix can act as an endogenous danger signals and are capable of triggering inflammatory processes (Schaefer L et al. J Clin Invest. 2005; 115:2223-33; Babelova A et al. J Biol Chem. 2009; 284:24035-48. Schaefer L & Iozzo RV. J Biol Chem. 2008; 283:21305-9). The major objective of the PhD project is the identification of novel drug targets for the inhibition of these pro-inflammatory effects.

The applicant should have an excellent degree in biology, biochemistry or a related life science. Knowledge and skills in molecular biology, cell biology and biochemistry, and the willingness to work with animals are desirable. If you are creative, self-motivated and a team player, we will be pleased to receive your application.


Further Information at:

www.klinik.uni-frankfurt.de/zpharm/allg/schaefer.html
If you are interested in working with us, please send your application including
(CV with picture) references via e-mail to
Frau Prof. Liliana Schaefer ( ).

 

 

GRK1172 “Biologicals” has been evaluated positively by the DFG (Deutsche Forschungsgemeinschaft) and been granted a continuation for another 4.5 years.

New PhD studentships

Our academic goal is to train excellent graduate students for careers in molecular medicine, pharmacy, biology and medicine both in academia and industry. The GRK 1172 research training group (at the Goethe University Frankfurt, the Goethe University Hospital and the Georg Speyer Haus) is embedded in the Graduate Centre FIRST (Frankfurt International Research School for Translational Biomedicine) of the Goethe Graduate Academy (GRADE). FIRST provides postgraduate education in all aspects of translational biomedicine with a focus on the processes involved in drug research and development.

Candidates should already possess an excellent MSc/Diplom or
Staatsexamen (biology, pharmacy or related discipline)or MD degree. Applications consist of:

• a cover letter indicating personal research goals and project references,
• a full curriculum vitae containing a brief summary of previous research projects,
• copies of all relevant university certificates.

Incomplete applications will not be considered. Please note the application deadline.


The following PhD projects are available:

Graduate Student Position available
A PhD student position is available from October 2010 in the group of Dr. Martin Zörnig. Our laboratory is interested in apoptosis and cancer research, and the project will focus on the function of FUSE Binding Protein 1 in Hepatocellular Carcinoma (Rabenhorst et al., Hepatology 2009).
We offer the possibility to be trained in interesting working techniques (including mammalian cell culture, viral transduction and analysis of mouse models) in a stimulating and cooperative working atmosphere.
The position will be financed by a scholarship from the Graduiertenkolleg 1172 (GK1172; please visit www.grk-1172.de; payment is equivalent to BATIIa/2) and implies a training program in tumor biology and biologicals).

Please send your application (including CV, letter of motivation, name and address of two referees) by mail/email to:

PD Dr. Martin Zörnig
Georg-Speyer-Haus – Institute for Biomedical Research
Paul-Ehrlich-Strasse 42-44
D-60596 Frankfurt / Main
Germany
E-mail:
Telephone: +49/(0)69-63395-115