PhD students

Dear new GRK1172 members

On behalf of the DFG funded Research Training Group GRK 1172 Biologicals and its steering committee it is our pleasure to welcome you as a new member and to offer thanks for your enthusiasm and interest in the group. We are glad you have decided to join us.

Name	Title of dissertation	Supervisor	Motto
Bajer, Magdalena	Charakterisierung des Wirkmechanismus und Analyse der anti-Tumor Aktivität naturstoffbasierter Stabilisatoren des Tumorsuppressors Pdcd4	Brüne/Schmid	"Nearly all the best things that came to me in life have been unexpected, unplanned by me." (Carl Sandburg)

Langner, Janina	Kontrolle der viralen Replikation durch synthetische Riboswitche	Suess	"Unsere größte Schwäche liegt im Aufgeben. Der sicherste Weg zum Erfolg ist immer, es doch noch einmal zu versuchen." (Thomas Alva Edison)

Qi, Zhou		Buchholz

Scheiermann, Patrick	Das therapeutische Potential von Interleukin-22 bei systemischer Entzündung	Mühl

Schmithals, Christian	Improvement of drug delivery in a transgenic HCC mouse model	Piiper	"There is nothing wrong with challenging conventional wisdom -- continuing challenge is a core feature of science……" (Wesley R. Elsberry)

Steinmeyer, Nico	Regulation and function of neuronal Hu-like mRNA-binding proteins in cancer and disease	Eberhardt	"In der Wissenschaft gleichen wir alle nur den Kindern, die am Rande des Wissens hier und da einen Kiesel aufheben, während sich der weite Ozean des Unbekannten vor unseren Augen erstreckt." (Isaac Newton)

Our PhD-Team

Name	Title of dissertation	Supervisor	Motto
Abel, Tobias	Selective gene transfer into the endothelial system by lentiviral vectors	Buchholz	Impossible! - So What?!

Abriss, Daniela	Non-viral gene transfer for hemophilia A therapy in the mouse model	Tonn	Failure is simply the opportunity to begin again, this time more intelligently.

Al- Ghaili, Nabil	Role of TCR diversity during genesis of T cell leucemia in mouse models	von Laer	If there is a will, there is a way.

Bajer, Magdalena	Characterisation of active natural compounds as stabilisers of the tumor suppressor Pdcd4.	Brüne/Schmid	"Nearly all the best things that came to me in life have been unexpected, unplanned by me." (Carl Sandburg)

Becker, Yvonne	Inhibition of the oligomerization of AML1/ETO by cell permeable peptides	Grez	"The great tragedy of science is the slaying of a beautiful hypothesis by an ugly fact." (Thomas Henry Huxley)

Brauer, Frances	Design of non-immunogenic peptides for HIV-1 entry inhibition	von Laer	"Science is based on the experience that nature answers intelligent questions intelligently, so if she is silent there may be something wrong with the question." (Albert Szent-Györgyi)

Brehm, Claudia	Adaptive immune therapy using NK cells and inhibitors of histone deacetylase after allogenic stem cell transplantation	Köhl	"Doubt is the father of invention.” (Galileo Galilei)

Brendel, Christian	Development of lentiviral vectors for the gene-therapy of the X-linked form of chronic granulomatous disease Auszeichnung: Preis in Leukerbad 2008	Grez	"Die Neugier steht am Anfang jeden Problems, das gelöst werden will." (Galileo Galilei)

Burkhardt, Ute	Recombinant tumor vaccines 11/2009 UCT-Best Abstract Forschungspreis	Wels	Key antigens for constructing cancer vaccines are identified and we are beginning to learn how to put them together - getting closer to our major goal: human benefit.

Doberstein, Kai	Regulation of the L1 cell adhesion molecule in kidney tumor cells	Pfeilschifter	"A scientist is happy, not in resting on his attainments but in the steady acquisition of fresh knowledge." (Max Planck)

Eißmann, Moritz	Identification and analysis of new anti apoptotic proteins expressed in therapy resistant tumors	Zörnig	"If you are out to describe the truth, leave elegance to the tailor." (Albert Einstein)

Fischer, Astrid	Role of 5-Lipoxygenase in proliferation and death of pancreatic cancer cells	Steinhilber	"If we knew what it was we were doing, it would not be called research, would it?" (Albert Einstein)

Giegold, Oliver	Role of CXCR3 and CXCR4 for transmigration of immune cells in chronic inflammation	Radeke	If at first, the idea is not absurd, then there is no hope for it.

Jabulowsky, Robert	Recombinant effector molecules of the apoptosis cascade for tumor therapy	Wels	"Thinking is more interesting than knowing, but less interesting than looking." (Johann Wolfgang von Goethe)

Kaufmann, Kerstin	Improved vectors for the gene therapy of X-linked chronic granulomatous disease	Grez	“Imagination is more important than (just) knowledge.” (Albert Einstein)

Kimpel, Janine	Mouse models for gene therapy of HIV infection	von Laer	“Real is what can be measured.” (Max Planck)

Knopp, Christiane	Chimeric cytokine receptors linking antibody-mediated tumor cell recognition with lymphocyte activity and survival	Wels	"Die Neugier steht immer an erster Stelle eines Problems, das gelöst werden will." (Galileo Galilei)

König, Melanie	Multivariate analysis of age-matched immune reconstitution after allogenic stem cell transplantation from patients with acute leukemia	Köhl	"Discovery consists of seeing what everybody has seen and thinking what nobody has thought." (Albert Szent-Györgyi)

Kraus, Benjamin	Reactivation of human endogenous retrovirus (HERV-K) in cancer and HIV patients: new antigens for vaccination	Schnierle	One of the secrets of life is to make stepping stones out of stumbling blocks.

Kynast, Katharina	Role of microRNA during the development and processing of pain	Niederberger	Das ganze Leben ist ein Quiz - und wir sind nur die Kandidaten.

Langner, Janina	Control of viral replication by engineered riboswitches	Suess	"Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time." (Thomas Alva Edison)

Lindner, Sabine	Influence of Toll-like receptor 2 ligands on the Leukotriene biosynthesis in human monocytes	Steinhilber	Es ist spannend, mit jedem Schritt wieder ein bisschen mehr zu verstehen.

Lyssy, Patricia	New strategies for therapies of hemophilia and thrombosis: generation / screening of FIX mutants and transfer to an animal model; screening of FIX inhibitors	Tonn	"The most beautiful thing we can experience is the mysterious. It is the source of all true art and science." (Albert Einstein)

Moeser, Christine	I-kappa B kinases as novel targets for the pharmacotherapy of pain and inflammation	Niederberger	"In nature we never see anything isolated, but everything in connection with something else which is before it, beside it, under it and over it." (Johann Wolfgang von Goethe)

Muik, Alexander	Generating LCMV-GP pseudotyped VSV-based systems for a potential treatment of glioblastoma	von Laer	"All life is problem solving" (Karl Reimund Popper)

Myladoor, Sunitha	Die Rolle des akzessorischen viralen Proteins Vpx bei der Transduktion von ruhenden Zellen mit lentiviralen Vektoren der SIVsmm/SIVmac/HIV2 Gruppe	Schweizer	"Anyone who has never made a mistake has never tried anything new." (Albert Einstein)

Neske, Christina	Role of p47phox and possible interaction partners for TLR signaltransduction in dendritic cells	Radeke	"Es kommt nicht darauf an mit dem Kopf durch die Wand zu rennen, sondern mit den Augen die Tür zu finden." (Werner von Siemens)

Oberoi, Pranav	Targeted Induction of tumor-cell death by apoptosis-inducing antibody fusion proteins	Wels	Research is the art of seeing what everyone else has seen, and doing what no-one else has done.

Pahujani, Shweta	Development of a safety-modified retroviral vector for a gene therapy of HIV infection	von Laer	I believe that cosmic religiousness is the strongest and most noble driving force of scientific research.

Qi, Zhou		Buchholz

Rabenhorst, Uta	In vitro and in vivo analysis of the transcriptional regulator FUSE Binding Protein 1 12/2009, Paul-Ehrlich-Förderpreis - verliehen vom Verein Freunde und Förderer des Georg Speyer Hauses e.V. und der Gesellschaft der Freunde Paul Ehrlichs e.V.	Zörnig	"Per aspera ad astra." (Seneca)

Roth, Stefanie	Optimization of recombinant Factor VIII production in heterologous cell systems and analysis of its secretion pathway Poster Prize September 2008 at the DGTI, honoured for excellente sientific work	Tonn	Unexpected results are often the better ones in research!

Rudloff, Ina	Regulation, function and therapeutic potential of IL-22 in inflammation	Mühl	"The future belongs to those who believe in the beauty of their dreams" (Eleanor Roosevelt)

Russe, Quintus	Untersuchungen zur Rolle von NF-kappaB- modulierenden Kinasen bei entzündlichen Schmerzen	Niederberger	Non quia difficilia sunt non audemus, sed quia non audemus difficilia sunt

Salzmann- Manrique, Emilia	Multivariate models for the evaluation of clinical studies and biological data	Köhl	"The most beautiful thing we can experience is the mysterious. It is the source of all true art and all science. He to whom this emotion is a stranger, who can no longer pause to wonder and stand rapt in awe, is as good as dead: his eyes are closed." (Albert Einstein)

Scheiermann, Patrick	Das therapeutische Potential von Interleukin-22 bei systemischer Entzündung	Mühl

Schmithals, Christian	Improvement of drug delivery in a transgenic HCC mouse model	Piiper	"There is nothing wrong with challenging conventional wisdom -- continuing challenge is a core feature of science……" (Wesley R. Elsberry)

Schröder, Matthias	Endogenous sphingolipids, analoga and their metabolism in dendritic cells	Radeke	Wenn die Klügeren immer nachgeben, geschieht nur das, was die Dummen wollen.

Schultze-Strasser, Stephan	Molecular monitoring of a clinical phase I/II gene therapy trial for X-CGD (X linked chronic granulomatous disease) Auszeichnung: Juli 2007 Best-Presentation-Award of the Deutsche Gesellschaft für Gentherapie (DG-GT, German Society for Gene Therapy)	Grez	Science has to be fun as it’s hard work.

Sokocevic, Alma	Synthesis and characterisation of Parvulustat and its derivatives	Engels	Don´t say always what you know, but always know what you say.

Steinmeyer, Nico		Eberhardt

Steinmetz, Cornelia	Adipositas-aktivierte Makrophagen als pharmakologisches Ziel in der Behandlung diabetischer Wundheilungsstörungen	Frank	"Nur wenige wissen, wie viel man wissen muss, um zu wissen, wie wenig man weiß" (Werner Heisenberg)

Steber, Markus	Regulation of the 5-Lipoxygenase expression by miRNA	Steinhilber	Thinking lateral and working forward in the field of RNA.

Volk, Andreas	Development of AAV-derived vectors for antiviral HIV gene therapy	von Laer	"The important thing is not to stop questioning." (Albert Einstein)

Weiß, Astrid	Survivin, an inhibitor of apoptosis proteins, as a target for a peptide-based therapy of human breast cancer	Groner	"The man of action has to believe, the inquirer has to doubt - the scientific investigator is both." (Charles Sanders Peirce)

Zhou, Mingkui	The role of neutralizing antibodies in HIV-1 infected elite controllers	Dietrich	In doing we learn.